Why the Passing of American Icon Sam Shepard Should Remind You of the Importance of InnovationALS, which killed Shepard, is the focus of entrepreneurs working in healthcare to rid us of this and lesser-known diseases.
ByJoan Oleck•
At the close of the 1970s, I had a fierce crush onSam Shepard, the eminent American playwright. Not only was he a serious intellectual for the plays he wrote, like the Pulitzer Prize-winningBuried Childand (a few years later),True WestandFool for Love,but in 1978, he made his screen debut in the Terrence Malick masterpiece,Days of Heaven。
Playing a hunky fictional Texas landowner in 1916 targeted by two Chicago grifters (Brooke Adams and Richard Gere), Shepard's character rose above the couple's heinous plot -- and won the girl, to boot.
Related:How Tiny Lab-Grown Innovations Are Making a Major Impact in Medicine and Industry
More important, to me, he seemed to literally represent America, especially its untamed Western frontier, as he filled the screen, standing amid the waving wheatfields of the Texas Panhandle, in yet another one of Malick's many gorgous tableaux. Shepard's character was a tall, handsome man of few words.
Actually, though, this literary icon gave us a lot of words, in his plays, screenplays (Paris, Texaswon the Cannes festival's grand prize) and movie roles -- most famouslyThe Right Stuff,in which he played another iconically American figure: the astronaut Chuck Yeager. For his depiction of the uber-brave Yeager, Shepard was nominated for an Oscar. (Fun fact: His playThe Unseen HandinfluencedThe Rocky Horror Picture Show.)
For all that, I was truly saddened to hear that Shepard died last week, at the relatively young age of 73, of ALS, or amyotrophic lateral sclerosis, the same degenerative nerve disease that killedanotherreally, really big American name, Yankee great Lou Gehrig.
But Gehrig died in 1939. So, 78 years later, how far have all those science-technology companies, large and small (especially small), gotten in their search for a cure? This terrible ailmentkills 6,000 Americans a year -- with an estimated 30,000 of uscurrently affected.
Speaking personally, I feel a tiny, second-degree-of-separation connection to Sam Shepard: In the year afterDays of Heavencaptured my imagination, I was at my novelist-friend Howard's Cambridge apartment, sitting in his tiny kitchen, discussing our mutual love of movies, especiallyDays。Sheepishly, Howard confessed that Shepard was actually a close friend.
Then the phone rang. "You old dog! Speak of the devil!" Howard said into the mouthpiece. Yup, it was Shepard on the line. And there I was, freaking out, acting out my fandom crush, mouthing the dumb words, "Tell him Joan thinks he's amazing!"
But that was many years ago, and ALS still takes its toll.
There is at least some good news: TheFDA in May approved Radicava, the first ALS drug greenlighted in 22 years on an application by the Mitsubishi Tanabe Pharma Corporation, a subsidiary of the tech giant.
I applaud theestimated 800 clinicians, scientists and companiesworking on ALS -- quietly, bravely laboring away, treating patients and testing and developing drugs to halt ALS's suspected genetic origins. Their efforts remind me of how important innovation is in America, whether it's literary or scientific in nature.
In the latter context, I'm reminded of how I was among the first wave of American children to be vaccinated against the-then deadly childhood plague of polio. It was that innovation, by scientist Jonas Salk, which turned a nightmare into a memory (at least here in the United States).
今天,许多生物技术创业公司狗万官方keeping up the fight against diseases like ALS -- diseases not as commonly discussed as polio once was, or as HIV, heart disease and cancer are in current times.
I hope all those entrepreneurs out there find a cure for ALS. And I hope they do that before the next American icon passes -- or anyone for that matter. That will surely be one of those "days of heaven" for us all.
